Dr. Alexander Shulgin's TiHKAL (1997)


Dr. Alexander Shulgin's PiHKAL (1991)


Crack (1980s)


John Lilly's The Scientist (1978)


DEA (1973)


war on drugs (1972)


Fear and Loathing in Las Vegas (1971)


Controlled Substances Act (1970)


Carlos Castaneda's The Teachings of Don Juan: A Yaqui Way of Knowledge (1968)


Owsley Stanley's lab (1967) was raided by police


DOM (1967)


the Summer of Love (1967)



the Merry Pranksters (1964)


the Millbrook estate (1963-1968)



Mary Pinchot Meyer (1962) turned JFK on to psychedelics


Ketamine (1962)



the Harvard Psilocybin Project (1960-1962)


PCP (1950s)



antidepressants (1950s)



Lysergic acid diethylamide (April 16, 1943)


Methadone (1937)


DMT (1931) was synthesized



MDMA (December 24, 1912)


Mescaline (1897) was isolated by the German Arthur Heffter


Ephedrine (1885)


Sigmund Freud (1884) Über Coca


Heroin (1874) was first synthesized  by C.R. Alder Wright



Angelo Mariani (1863) started marketing a wine called Vin Mariani which had been treated with coca leaves


cocaine (1855)



Friedrich Wilhelm Sertürner (1804) isolated morphine from opium


Nitrous oxide (1790s)




St John's wort








the opium poppy


Ma Huang



Ancient Babylonians (4000 bc) were the first people to brew alcoholic beverages



Druids (7000 bc) pioneered the use of psilocybian mushrooms





Stone age hunters (10,000 bc) and gatherers first used hemp