Dr. Alexander Shulgin's TiHKAL (1997)

 

Dr. Alexander Shulgin's PiHKAL (1991)

 

Crack (1980s)

 

John Lilly's The Scientist (1978)

 

DEA (1973)

 

war on drugs (1972)

 

Fear and Loathing in Las Vegas (1971)

 

Controlled Substances Act (1970)

 

Carlos Castaneda's The Teachings of Don Juan: A Yaqui Way of Knowledge (1968)

 

Owsley Stanley's lab (1967) was raided by police

 

DOM (1967)

 

the Summer of Love (1967)

 

 

the Merry Pranksters (1964)

 

the Millbrook estate (1963-1968)

 

 

Mary Pinchot Meyer (1962) turned JFK on to psychedelics

 

Ketamine (1962)

 

 

the Harvard Psilocybin Project (1960-1962)

 

PCP (1950s)

 

 

antidepressants (1950s)

 

 

Lysergic acid diethylamide (April 16, 1943)

 

Methadone (1937)

 

DMT (1931) was synthesized

 

 

MDMA (December 24, 1912)

 

Mescaline (1897) was isolated by the German Arthur Heffter

 

Ephedrine (1885)

 

Sigmund Freud (1884) Über Coca

 

Heroin (1874) was first synthesized  by C.R. Alder Wright

 

 

Angelo Mariani (1863) started marketing a wine called Vin Mariani which had been treated with coca leaves

 

cocaine (1855)

 

 

Friedrich Wilhelm Sertürner (1804) isolated morphine from opium

 

Nitrous oxide (1790s)

 

Khat

 

St John's wort

 

Tobacco

 

Peyote

 

Ayahuasca

 

the opium poppy

 

Ma Huang

 

 

Ancient Babylonians (4000 bc) were the first people to brew alcoholic beverages

 

 

Druids (7000 bc) pioneered the use of psilocybian mushrooms

 

Caffeine

 

 

Stone age hunters (10,000 bc) and gatherers first used hemp