Dr. Alexander Shulgin's TiHKAL (1997)
Dr. Alexander Shulgin's PiHKAL (1991)
Crack (1980s)
John Lilly's The Scientist (1978)
DEA (1973)
war on drugs (1972)
Fear and Loathing in Las Vegas (1971)
Controlled Substances Act (1970)
Carlos Castaneda's The Teachings of Don Juan: A Yaqui Way of Knowledge (1968)
Owsley Stanley's lab (1967) was raided by police
DOM (1967)
the Summer of Love (1967)
the Merry Pranksters (1964)
the Millbrook estate (1963-1968)
Mary Pinchot Meyer (1962) turned JFK on to psychedelics
Ketamine (1962)
the Harvard Psilocybin Project (1960-1962)
PCP (1950s)
antidepressants (1950s)
Lysergic acid diethylamide (April 16, 1943)
Methadone (1937)
DMT (1931) was synthesized
MDMA (December 24, 1912)
Mescaline (1897) was isolated by the German Arthur Heffter
Ephedrine (1885)
Sigmund Freud (1884) Über Coca
Heroin (1874) was first synthesized by C.R. Alder Wright
Angelo Mariani (1863) started marketing a wine called Vin Mariani which had been treated with coca leaves
cocaine (1855)
Friedrich Wilhelm Sertürner (1804) isolated morphine from opium
Nitrous oxide (1790s)
Ancient Babylonians (4000 bc) were the first people to brew alcoholic beverages
Druids (7000 bc) pioneered the use of psilocybian mushrooms
Stone age hunters (10,000 bc) and gatherers first used hemp